Past Research Projects

Funded by The Children's Heart Association of Cincinnati

CICU Special Purpose Fund

Funding Timeline:  2015
Amount Funded:  $10,000

This funding was provided for patients or parents of children confined to Cincinnati Children’s Cardiac Intensive Care Unit. Often families are forced to stay for months at a time to manage their child’s care and find themselves unable to work. Meeting their basic needs can become difficult, especially when they are trying to support other children back home. This funding is used to help alleviate the burden on these families.

Vascular Ultrasound Research Imaging System

Primary Investigator:  Thomas Kimball, MD
Funding Timeline:  2006-2009

This funding allowed purchases of additional echocardiography equipment for the Echocardiography Research Laboratory. This equipment enabled the Laboratory to expand its efforts to the broader academic community and provided a more robust menu of techniques to evaluate cardiac and vascular anatomy and function.

Endo-PAT 2000 to Measure Premature Arterial Damage in Children

Primary Investigator:  Elaine Urbina, MD
Funding Timeline:  2006-2008

This funding enabled purchase of unique noninvasive tools for the study of hardening of the arteries in children. These tools have subsequently been used in numerous research projects, including many funded by the American Heart Association and NIH, to study arterial disease in children with a variety of conditions including obesity, diabetes, kidney disease and lung problems. This device is now being applied to children with congenital heart disease including single ventricle patients after Fontan operation.

Feasibility of Transhepatic Cardiac Cath in Fetal Lambs

Primary Investigator:  Erik Michelfelder, MD
Funding Timeline:  2004-2007

This research evaluated unique methods for performing cardiac catheterization in the fetus using a lamb model. Developing better means for intervening on congenital heart disease in the fetus could impact survival of babies with complex heart problems.

Fetal Cardiovascular Research Study

Primary Investigator:  Pirooz Eghtesady, MD, PhD
Funding Timeline:  2004-2007

This study examined cardiovascular surgical methods, physiology, anesthetic response and the pathogenesis of congenital heart disease in the fetus using a sheep model.

This Children’s Heart Association of Cincinnati supported research provided important results used in research subsequently funded by the American Heart Association and other agencies. The studies have contributed to our understanding of fetal physiology and enhance our ability to perform cardiac interventions in fetuses with heart disease.

NIH Grant Clinical Research Coordinator Position

Primary Investigator:  Steve Daniels, MD
Funding Timeline:  2002-2006

Clinical research studies conducted:

  • Sibutramine Adolescent Study Group. Cardiovascular effects of sibutramine in the treatment of obese adolescents: results of a randomized, double-blind, placebo-controlled study.
  • Progression of left ventricular hypertrophy in children with early chronic kidney disease: 2-year follow-up study.
  • Interactions between noncontiguous haplotypes in the adiponectin gene ACDC are associated with plasma adiponectin.
    Diastolic filling abnormalities in children with essential hypertension.
  • Cardiac and vascular adaptation in pediatric patients with chronic kidney disease: role of calcium-phosphorus metabolism.
  • The relationship of health outcomes to improvement in BMI in children and adolescents.
  • Blood pressure and total peripheral resistance in children with chronic kidney disease.
  • Impaired left ventricular diastolic function in children with chronic renal failure.
Research Cardiac Catheterization Laboratory

Primary Investigator: Kathy Wright, DVM
Funding Timeline: 2000-2006

These studies contributed to our understanding of fetal physiology and enhanced our ability to perform cardiac interventions in fetuses with heart disease. They also added to our understanding of how the heart contracts, and ultimately, to a means of improving the performance of dysfunctional hearts. Studies conducted in part in the Laboratory helped secure a major National Institutes of Health (NIH) grant and resulted in multiple publications.

Heart Institute Encyclopedia

Primary Investigator:  Peter Manning, MD and Robert Beekman, MD
Funding Timeline:  2002

With the financial support of the Children’s Heart Association of Cincinnati, The Heart Institute team at Cincinnati Children’s Hospital Medical Center developed the Heart Institute Encyclopedia to provide easily accessible information on cardiac diseases, defects, disorders, and problems that may affect a child’s heart. The Heart Institute Encyclopedia also provides information about options available to diagnose and treat children’s heart conditions and anomalies.

Bicuspid Aortic Valve Study

Primary Investigator:  Woody Benson, MD, PhD
Funding Timeline:  2002

This study investigated the genetic patterns of inheritance of bicuspid aortic valve. Results showed that inheritance of some valve formations was much greater than expected. Support from CHOAC was used to fund research echocardiograms needed for preliminary data for a grant submission, subsequently funded by the NIH.

Echocardiography Research Laboratory

Primary Investigator:  Thomas Kimball, MD
Funding Timeline:  1994-1997

The Children’s Heart Association of Cincinnati provided seed money for the initial operational funding of the Heart Institute’s Echocardiography Research Laboratory. This funding provided the ability of the Laboratory to obtain independent grant support. The Laboratory has become the standard of echocardiography research laboratories across the country and has been the source of numerous grants, discoveries and publications.

The Fitness Class of 2000 – “The Princeton Study”

Primary Investigator:  John Morrison, MD
Funding Timeline:  1989-Present

Healthy students 3rd through 5th within the Princeton School District took part in this study of childhood predictors of adult coronary artery disease, measuring blood pressure, height, weight, cholesterol and measures of body size. These children, who are now adults, are still being followed today.

Early Funding

1940:  Children’s Heart Association of Cincinnati supports the salaries of doctors, nurses and technicians of the newly formed cardiac clinic at Cincinnati Children’s

1948:  CHAoC established EKG service

1950:  Drs. Rauh and Lyons, founding members of CHAoC, recruit Dr. Samuel Kaplan as a cardiology fellow and surgeon, Dr. James Helmsworth, and support their salaries. Dr. Kaplan, along with Dr. Leland Clark, would go on to develop the mechanical heart-lung machine in 1953 and found the Division of Cardiology in 1954.

1952:  Adolescent clinic establised and sponsored by CHAoC

1954:  Fluoroscope funded by CHAoC

1955:  X-ray equipment that was a precursor to cardiac angiography funded by CHAoC

1957:  CHAoC provides funding for fellowships

1965:  X-ray equipment funded by CHAoC

1978:  Echo equipment funded by CHAoC
 

We are proud to support The Heart Institute at Cincinnati Children's Hospital Medical Center.

We are proud to support The Heart Institute at Cincinnati Children’s Hospital Medical Center.